How should sublingual nitroglycerin tablets be taken?

Sublingual nitroglycerin tablets are designed to provide rapid relief from angina (chest pain) by allowing the medication to dissolve under the tongue, where it can quickly enter the bloodstream. Placing the tablet under the tongue allows it to bypass the digestive system, enabling faster absorption and more immediate relief. It is also important to wait at least 5 minutes between doses if the chest pain persists, as this approach helps to ensure safety and prevent overdose while providing time for the medication to take effect.

The method of taking sublingual nitroglycerin is crucial for its efficacy, as swallowing the tablet or chewing it would impede the quick absorption necessary for relief. Additionally, crushing and mixing the tablet with food would alter the way the medication is delivered, delaying its onset of action, which is not suitable for a condition that requires immediate relief.